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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ADRA2A
All Species:
22.12
Human Site:
T227
Identified Species:
44.24
UniProt:
P08913
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.27
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P08913
NP_000672.3
450
48957
T227
Y
Q
I
A
K
R
R
T
R
V
P
P
S
R
R
Chimpanzee
Pan troglodytes
XP_521603
468
50335
R218
T
R
V
P
P
S
R
R
G
P
D
A
V
A
A
Rhesus Macaque
Macaca mulatta
XP_001087738
450
49113
T227
Y
Q
I
A
K
R
R
T
R
V
P
P
S
R
R
Dog
Lupus familis
XP_544018
622
67080
T242
Y
Q
I
A
K
R
R
T
R
V
P
P
S
R
R
Cat
Felis silvestris
Mouse
Mus musculus
Q01338
450
48847
T227
Y
Q
I
A
K
R
R
T
R
V
P
P
S
R
R
Rat
Rattus norvegicus
P22909
450
48921
T227
Y
Q
I
A
K
R
R
T
R
V
P
P
S
R
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513049
394
43582
Y205
L
E
V
H
L
S
S
Y
I
F
T
A
T
C
S
Chicken
Gallus gallus
XP_426355
614
69002
T401
Y
R
V
A
K
L
R
T
R
T
L
S
E
K
R
Frog
Xenopus laevis
P24628
442
49720
V217
L
R
K
R
R
K
R
V
N
T
K
R
N
S
R
Zebra Danio
Brachydanio rerio
Q90WY4
388
43978
R199
I
M
V
L
V
Y
I
R
I
Y
Q
I
A
K
K
Tiger Blowfish
Takifugu rubipres
P53453
463
52101
R221
Y
V
V
L
R
K
R
R
K
R
V
N
T
K
P
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001200819
471
53401
A244
W
L
A
A
K
R
R
A
R
S
T
V
R
K
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
84.6
96.4
58.5
N.A.
92.2
90.8
N.A.
45.5
43
33.3
60.4
32.6
N.A.
N.A.
N.A.
36
Protein Similarity:
100
86.1
96.6
62
N.A.
94
92.8
N.A.
53.1
51.2
50.6
70.6
49.4
N.A.
N.A.
N.A.
53
P-Site Identity:
100
6.6
100
100
N.A.
100
100
N.A.
0
46.6
13.3
0
13.3
N.A.
N.A.
N.A.
33.3
P-Site Similarity:
100
20
100
100
N.A.
100
100
N.A.
20
66.6
40
26.6
53.3
N.A.
N.A.
N.A.
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
9
59
0
0
0
9
0
0
0
17
9
9
9
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
9
0
0
0
0
% D
% Glu:
0
9
0
0
0
0
0
0
0
0
0
0
9
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
9
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
9
0
0
0
0
0
0
% G
% His:
0
0
0
9
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
9
0
42
0
0
0
9
0
17
0
0
9
0
0
0
% I
% Lys:
0
0
9
0
59
17
0
0
9
0
9
0
0
34
9
% K
% Leu:
17
9
0
17
9
9
0
0
0
0
9
0
0
0
0
% L
% Met:
0
9
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
9
0
0
9
9
0
0
% N
% Pro:
0
0
0
9
9
0
0
0
0
9
42
42
0
0
9
% P
% Gln:
0
42
0
0
0
0
0
0
0
0
9
0
0
0
0
% Q
% Arg:
0
25
0
9
17
50
84
25
59
9
0
9
9
42
59
% R
% Ser:
0
0
0
0
0
17
9
0
0
9
0
9
42
9
17
% S
% Thr:
9
0
0
0
0
0
0
50
0
17
17
0
17
0
0
% T
% Val:
0
9
42
0
9
0
0
9
0
42
9
9
9
0
0
% V
% Trp:
9
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
59
0
0
0
0
9
0
9
0
9
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _